WebSep 2, 2024 · Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver. Atorvastatin also increases the number of LDL receptors on the surface of hepatic cells. This activity reviews the … WebApr 12, 2024 · Primary endpoint rates did not differ between the combo group (moderate-intensity statin plus ezetimibe) or the monotherapy group (high-intensity statin monotherapy group). For patients aged ≥75 years, the primary outcome rates were 10.6% for the combination group and 12.3% for the monotherapy group (hazard ratio [HR], 0.87; …
Comparing Statins: Intensity, Dosages, and More - GoodRx
WebMay 8, 2012 · There is randomized evidence that atorvastatin at 80 mg/day provides significant reductions in the risks of cardiovascular events and stroke beyond that afforded by a 10-mg dose in patients with coronary disease. 1 In the Treating to New Targets (TNT) trial, high-dose atorvastatin significantly reduced total cholesterol and triglycerides … WebJan 6, 2024 · Some evidence suggests that high-intensity statin therapy may help to slow, and potentially reverse, the growth of artery-clogging atherosclerotic plaques. They may … delta flights dc to orf
Is moderate exercise safe while taking statins? Lifestyle
WebMar 8, 2024 · Atorvastatin is considered a moderate- or high-intensity statin depending upon the dose: A dose of 10 to 20 mg per day is considered moderate-intensity therapy … WebOct 21, 2024 · High-intensity statins to reduce LDL-C by ≥50% are used for high-risk, and for those at intermediate-risk, moderate-intensity statin to reduce LDL-C by ≥30%. For the very high-risk patient based on LDL-C >189 mg/dl, nonstatins including ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors may be considered. WebFeb 17, 2024 · Statins are a class of medications used to lower high cholesterol and reduce the risk of heart attack and stroke. Atorvastatin, simvastatin, and rosuvastatin are common examples. Statin doses are often categorized as low, moderate, and high intensity. Atorvastatin and rosuvastatin are the only two statins with high-intensity … fetters construction auburn indiana