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Cisplatin ic50

WebJan 10, 2024 · The half maximal inhibitory concentration (IC50) of different OC cells after treatment with ( a) olaparib, ( b) niraparib and ( c) rucaparib, assessed by clonogenic assays. Data represents the mean ± SEM of triplicates of … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying …

Cisplatin remodels the tumor immune microenvironment via the

WebAfter an incubation with DDP/EXOs, the cell lines exhibited a higher IC50 value for cisplatin, P-gp expression, migration and invasion capabilities and a lower apoptosis … WebBackground: Cisplatin (Cp) is an antineoplastic agent with a dose-limiting nephrotoxicity. Cp-induced nephrotoxicity is characterized by the interplay of oxidative stress, inflammation, and apoptosis. shannon pumphrey little rock arkansas https://cleanbeautyhouse.com

HCG11 silencing inhibits cisplatin resistance in GC CMAR

WebJun 5, 2024 · E Cell viability of A2780 cells and resistant cells (A2780-CDDP) after were treated with cisplatin at corresponding concentrations for 48 h was detected by CCK-8 assay. Half maximal inhibitory... WebIC50 values were calculated. Evaluation of apoptosis and DNA damage were performed. In addition, the expression of pro-apoptotic and anti-apoptotic genes and proteins were tested. IC50 values indicated less toxicity of the Schiff base … WebFeb 5, 2016 · Cisplatin remains to be primary chemotherapeutic drug for gastric cancer patients, especially for advanced stage ones. However, primary or acquired resistance … shannon purdy

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Category:The changing 50% inhibitory concentration (IC50) of …

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Cisplatin ic50

AID 625684 - Ratio of cisplatin IC50 to compound IC50 for

WebJun 1, 2024 · The cisplatin IC50 of the MBA-MB-231 and MCF-7 cell lines decreased from 60 μmol/L to 40 μmol/L and from 40 μmol/L to 20 μmol/L, respectively. Similarly, the doxorubicin IC50 of the MBA-MB-231 and MCF-7 cell lines decreased from 15 μmol/L to 7.5 μmol/L and 5 μmol/L to 3 μmol/L, respectively. WebAug 27, 2024 · The combination of sodium butyrate with cisplatin decreased the IC50 value of cisplatin and attenuated the cytotoxic effect of cisplatin on the normal cells. Accordingly, we selected SGC-7901 cells and HGC-27 cells, which showed better sensitivities to sodium butyrate to perform the subsequent experiments.

Cisplatin ic50

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WebThe IC(50) was defined as the drug concentration required for a 50% reduction in optical density. Cytotoxicity assays were performed with four sequential combinations of a … WebApr 10, 2024 · The half-maximal inhibitory concentration values (IC 50) were calculated by interpolation from the nonlinear regression curves obtained from cell proliferation/cytotoxicity data using “log (inhibitor) versus the normalized response–variable slope equation”. A p -value lower than 0.05 was considered statistically significant. 3. Results

WebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor. WebBioAssay record AID 625684 submitted by ChEMBL: Ratio of cisplatin IC50 to compound IC50 for mouse B16F10.

WebFor comparison, cisplatin, a common clinical drug for bladder cancer, showed IC 50 values of 1.33 and 4.98 µg/mL for T24 and J82 cells at 48 h CCK-8 assay, respectively [27]. Cisplatin also... WebDownload scientific diagram Summary of IC50 values of sinomenine or cisplatin in gastric cancer cells. from publication: Sinomenine sensitizes human gastric cancer cells to …

WebThe DDP at a concentration of IC50 (AGS/DDP cells, 71.34 μM; MKN45/DDP cells, 61.28 μM) was used for further experiments. Bax and Bcl-2 are biomarkers of apoptosis. As illustrated in Figure 2E , the protein expression of Bax was remarkably elevated, while Bcl-2 was declined in AGS/DDP and MKN45/DDP cells following sh-HCG11 transfection or … pomerleau construction torontoWebA cisplatin-resistant cell subline, HeLa/CDDP cells, showed a 19-fold resistance to cisplatin compared with the parent cells. The subline showed a collateral sensitivity to … shannon purcell levittownWebApr 2, 2024 · IC50 values for ( a–d) bortezomib- and ( e–h) cisplatin-treated MCF7, HCC38, MCF-10A, and MDA-MB-436 breast cancer cells … shannon purdie