Cisplatin livertox

Author: hvkt

August undefined, 2024

WebCarboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue.This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich … WebNov 20, 2024 · Drug induced liver injury is an uncommon but important and challenging form of liver disease. When evaluating a patient with new-onset liver disease, drugs, including prescription drugs, over-the-counter preparations, dietary supplements, vitamins and herbal medications, must always be considered as a possible cause. Indeed, the possibility …

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]

WebSep 18, 2024 · National Center for Biotechnology Information WebPeginterferon alfa-2a is available as a fixed dose injector (tradename Pegasys) used for the treatment of chronic Hepatitis C. Approved in 2002 by the FDA, Pegasys is indicated for the treatment of HCV with Ribavirin or … ipcf88fip

www.ncbi.nlm.nih.gov

WebFeb 2, 2024 · Floxuridine - LiverTox - NCBI Bookshelf Floxuridine (FUDR) is a pyrimidine analogue used as an antineoplastic agent, usually as a continuous hepatic arterial infusion to treat hepatic metastases from … WebLiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012 In vitro phase II comparison of the cytotoxicity of a novel platinum analog, nedaplatin (254-S), with that of cisplatin and carboplatin against fresh, human ovarian cancers. [Cancer Chemother Pharmacol. 1997] WebDec 20, 2024 · The interrelationship between the liver and molecularly targeted agents used for cancer therapy are discussed elsewhere, as is hepatotoxicity associated with checkpoint inhibitor immunotherapy, as used for advanced melanoma and other solid tumors. orange and blue plaid

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebMar 9, 2024 · A typical dosing regimen is 30 minute infusions of 1.0 to 1.2 g/m 2 on days 1, 8 and 15 of each 28 day cycle of chemotherapy. Common side effects include bone marrow suppression, fatigue, diarrhea, nausea, … WebJun 23, 2024 · Durvalumab is a human monoclonal antibody to programmed cell death ligand 1 (PD-L1), which acts as a checkpoint inhibitor and is used in the immunotherapy of several forms of advanced … orange and blue plaid flannel shirtWebThe DILIrank dataset consists of 1,036 FDA-approved drugs that are divided into four classes according to their potential for causing drug-induced liver injury (DILI). The DILI classification is ... ipcas2ini

"WebIn combination with cisplatin for first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) As a single agent for the treatment of … " - Cisplatin livertox

Cisplatin livertox

LiverTox: Clinical and Research Information on Drug …

WebJun 3, 2024 · LiverTox has two major components: 1) an introduction and overview of drug-induced liver injury that includes discussions of clinical patterns, diagnostic criteria, and … WebCisplatin, doxorubicin and fluorouracil (5-FU), drugs belonging to different chemical classes, have been extensively used for chemotherapy of various cancers. Despite extensive investigations into their hepatotoxicity, there is very limited information on their effects on the structure and ultra-structure of liver cells in vivo.

Did you know?

Webwww.ncbi.nlm.nih.gov WebPrevention of Nausea and Vomiting Associated with Cisplatin Based Highly Emetogenic Cancer Chemotherapy . VARUBI 180 mg; Approximately 1 to 2 hours prior to chemotherapy None Dexamethasone 20 mg; 30 min prior to chemotherapy 8 mg twice daily 8 mg twice daily 8 mg twice daily 5-HT. 3 . receptor antagonist See the prescribing information for …

WebMar 10, 2015 · The platinum-containing antineoplastic agents [cisplatin, carboplatin, oxaliplatin], which are referred to as platinum coordination complexes. These antineoplastic drugs are usually classified as … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

WebCisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been … WebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose …

WebMay 7, 2024 · Corticosteroids - LiverTox - NCBI Bookshelf The corticosteroids are a group of chemically related natural hormones and synthetic agents that resemble the human adrenal hormone cortisol and have potent antiinflammatory and immunosuppressive properties and are widely used in medicine.

WebJan 1, 2013 · LiverTox has three major components: (1) introductory sections that describe DILI, including the course, diagnosis, clinical phenotypes of injury, immunological … ipcheck thaiwareWebMay 18, 2024 · Cisplatin (cis-diamminedichloroplatinum; CP) is an effective alkylating and antineoplastic agent that is widely used in the treatment of solid tumors. 1 The liver is a key organ in the metabolism and detoxification of endobiotics and xenobiotics. 2 CP is accumulated in liver cells, leading to hepatotoxicity. ipcr2023 orange and blue plaid flannel fabricWebJul 1, 2024 · LIVERTOX is a freely available website that provides up-to-date, comprehensive and unbiased information about drug induced liver injury caused by prescription and nonprescription drugs, herbal products … ipconfig for iosWebApr 5, 2024 · LiverTox® provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury … orange and blue rackingWebNational Center for Biotechnology Information ipcshishenmeWebCisplatin Vial. - Uses, Side Effects, and More. Cisplatin may cause severe kidney problems, nerve problems, and severe nausea and vomiting. Nerve problems may occur … orange and blue quilt bedding