WebExpression of DDIT4 (Dig2, FLJ20500, REDD-1, REDD1, RTP801) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... PANCREATIC CANCER - Interactive survival scatter plot i & Survival analysis i. DDIT4 is prognostic, high expression is unfavorable in pancreatic cancer ... WebPrognostic marker in renal cancer (unfavorable), pancreatic cancer (unfavorable) and head and neck cancer (unfavorable) Renal cancer p0.001. Cancer specificity i ... Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy ...
Research Article DDIT4 Novel Mutations in Pancreatic Cancer
WebMar 17, 2024 · The phosphorylation level of mammalian target of rapamycin complex 1 (mTORC1) is regulated by DDIT4, 34 located at the core of multiple metabolic pathways, and it is a target for tumor treatment, 35 especially in the cancer exhibiting activated AKT/mTORC cascade. 36 Functional studies proved that DDIT4 inhibited mTORC1 by … WebWe speculate that DDIT4 plays an important role in pancreatic cancer, but its specics are still unknown. Then, we investigated the role of DDIT4 in pancreatic cancer through … executive recruitment firms us healthcare
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Webmutations and the value of novel gene mutation in the DNA damage-inducible transcript 4 (DDIT4) and signaling pathway in pancreatic cancer. Polymerase chain reaction (PCR) was performed to amplify the DNA sequences of DDIT4 from patients with pancreatic ductal adenocarcinoma. In addition, we used IHC to detect the expression level of DDIT4 in ... WebSep 2, 2024 · The m 6 A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by … WebJun 9, 2024 · These genes included DNA-damage-inducible transcript 4 (DDIT4), sulfatase 1 (SULF1) as coding RNA genes and miR-181d-5p, miR-148b-3p and TPTE Pseudogene 1 (TPTEP1) as ncRNA genes. ... studies reported SULF1 as a tumor suppressor effector and its down-regulation levels related to several cancers such as … executive relocations