Des-γ-carboxy-prothrombin
WebOct 4, 2024 · To explore the diagnostic efficacy of des-gamma-carboxy prothrombin (DCP) in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC). A retrospective study of 459 cases from June 2016 to March 2024 was … Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or mal…
Des-γ-carboxy-prothrombin
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WebNov 15, 2024 · Des-γ-carboxy-prothrombin (DCP) is an abnormal prothrombin in which one or more glutamic acid residues of the Gla domain are not fully carboxylated to gamma-carboxylated glutamate (Gla) in its … WebOct 31, 2000 · Serum concentrations of des-γ-carboxy prothrombin (DCP) from 91 patients with hepatocellular carcinoma (HCC) and 57 with cirrhosis (LC) are shown. There is a statistically significant difference between the serum concentrations of DCP in HCC (48.3 ± 24.3, mean ± standard deviation) and those in cirrhosis (20.3 ± 10.3), as determined by …
WebPatients were also more likely to have a fibrosis-4 (FIB-4) index > 3.25, Child–Pugh class A, and higher serum levels of alpha-fetoprotein and Des-γ-carboxy prothrombin (DCP). They were treated with sorafenib ( n = 275), lenvatinib ( n = 48), or ATZ/BV ( n = 36) as first-line therapy for advanced HCC. WebZhu R, Yang J, Xu L, et al. Diagnostic performance of des-γ-carboxy prothrombin for hepatocellular carcinoma: a meta-analysis. Gastroenterol Res Pract. 2014;2014:529314. ... Post-ablation des-gamma-carboxy prothrombin level predicts prognosis in hepatitis B-related hepatocellular carcinoma. Liver Int. 2016;36(4):580–587. 27.
WebDes-γ-Carboxy Prothrombin. Serum concentrations of des-γ-carboxy prothrombin (DCP) (also known as prothrombin produced by vitamin K absence or antagonist II) are raised in most patients with HCC. 65 DCP is an abnormal prothrombin that is thought to result from a defect in the post-translational carboxylation of the prothrombin precursor …
WebApr 24, 2002 · Serum des-γ-carboxy prothrombin (DCP) is a useful marker for the diagnosis of hepatocellular carcinoma (HCC), but the exact mechanism of its synthesis …
WebSaito M, Seo Y, Yano Y, Miki A, Yoshida M, Azuma T. A high value of serum des-γ-carboxy prothrombin before hepatocellular carcinoma treatment can be associated with long-term liver dysfunction after treatment. J. Gastroenterol. 2012; 47 (10):1134–1142. doi: 10.1007/s00535-012-0577-0. [Google Scholar] the pokémon in the woodland photoWebObjective: To investigate the diagnostic value of des-γ-carboxy prothrombin (DCP) for recurrence in hepatocellular carcinoma (HCC) patients receiving precautionary sorafenib after curative liver resections. Methods: Eighty-five patients receiving curative hepatectomy and adjuvant sorafenib afterwards were enrolled. sidhil bed railsWebThe utility of AFP is limited by low sensitivity and specificity. 166 Many other serum biomarkers, such as des-γ-carboxy prothrombin, are becoming available, but their usefulness remains to be proved. Serum AFP level and US of the liver are recommended every 6 months for screening of patients at risk of developing HCC. 167. the pokemon game onlineWebNov 20, 2000 · Des-γ-carboxy prothrombin (DCP) is an established marker for hepatocellular carcinoma (HCC), but the conventional enzyme immunoassay (EIA) kit lacks adequate sensitivity. Thus, a revised EIA kit with increased sensitivity has been developed. In this kit, the sensitivity has increased while high specificity to HCC has been maintained. sid hicksWebObjectives: The aim of this study was to investigate the relationships between early changes in the tumor markers α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), and antitumor response in the early period following administration of sorafenib in patients with advanced hepatocellular carcinoma (HCC). Methods: Forty-eight advanced HCC patients … the pokemon company ukWebNov 25, 2024 · This prospective study investigated the impact of cabozantinib exposure on proteinuria and muscle toxicity, in a cohort of 14 Japanese patients with unresectable hepatocellular carcinoma (uHCC). We measured the trough concentration of cabozantinib (Ctrough) weekly for 6 weeks after starting treatment. Although the initial dose was less … sidhi in which stateWebWe detected des-γ-carboxy prothrombin, an abnormal prothrombin, in the serum of 69 of 76 patients (91 per cent) with biopsy-confirmed hepatocellular carcinoma (the mean level of the abnormal ... sidh industries ltd. value research online