WebHard-metal (WC-Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1alpha, HMOX1, and p53 activation in human peripheral blood mononucleated cells. Peroxisome proliferator-activated receptor delta agonist attenuates nicotine suppression effect on human mesenchymal stem cell-derived osteogenesis and involves increased expression of … Web14 de jul. de 2024 · To determine whether HIF-1, HIF-2, ... Although expression of HMOX1 was not significantly altered by MAFF knockdown, we found binding peaks on two known HMOX1 promoter regions 23.
Targeting Heme Oxygenase-1 for Neuroprotection and …
Web19 de out. de 2024 · Intestinal barrier dysfunction is a significant clinical problem, commonly developing in a variety of acute or chronic pathological conditions. Herein, we evaluate the effect of microRNA-31 (miR-31) on intestinal barrier dysfunction through NF-κB/HIF-1α pathway by targeting HMOX1 in rats with sepsis. Male Sprague-Dawley rats were … Web12 de mar. de 2024 · Because HIF1α regulates Hmox1 induction in response to stressful stimuli, including hypoxia , we examined whether Nrf2 regulates hypoxia-inducible Hmox1 expression through HIF1α activation. Primary murine RTECs were isolated from Nrf2 -deficient ( Nrf2 –/– ) and Nrf2 -sufficient (WT) mice and treated with HIF1α activator CoCl … fish taco sauce heb
MiR-31 regulated expression of the NF-κB/HIF-1α pathway …
Web21 de mar. de 2024 · HMOX1 (Heme Oxygenase 1) is a Protein Coding gene. Diseases associated with HMOX1 include Heme Oxygenase 1 Deficiency and Pulmonary Disease, Chronic Obstructive.Among its related pathways are Nuclear events mediated by NFE2L2 and Inflammasomes.Gene Ontology (GO) annotations related to this gene include … Web15 de mar. de 2024 · Further experiments also confirmed ferroptosis in Leydig and Sertoli cells. Using Western blotting, cellular immunofluorescence and ChIP-qPCR, we found that MEHP exposure caused HIF-1α accumulation and stabilization, resulted in HIF-1α translocation into the nucleus, and induced HIF-1α/Hmox1 binding in Leydig and Sertoli … Web28 de set. de 2012 · This cascade implies p38/MAP kinase activation, HIF-1α stabilization, HMOX1 transcriptional activation, and ATM-independent p53 stabilization. These events, and in particular HIF-1α stabilization, could contribute … fish taco recipe with mahi mahi