WebMar 26, 2024 · Without the J-chain, IgA antibodies are secreted as monomers and are not actively transported across the mucosal epithelium [ 20 ]. After transport of the J-chain/pIgR complex to the apical portion of the cell, pIgR is cleaved, releasing secretory IgA (sIgA) into breast milk and other mucosal fluids ( Fig 1B) [ 21 ]. Webimmunoglobulin joining chain. Synonyms. 9530090F24Rik, Igj, Jch, J chain Feature Type. protein coding gene ... PR:000008965 immunoglobulin J chain (term hierarchy) PDB. 7JG1, 7JG2. InterPro Domains. IPR024110 Immunoglobulin J chain. Molecular Reagents less. All nucleic 113. cDNA 111.
Influence of tonsillar disease on the expression of J chain by
WebFeb 6, 2024 · Immunoglobulin M (IgM) plays a pivotal role in both humoral and mucosal immunity. Its assembly and transport depend on the joining chain (J-chain) and the … WebOct 10, 2024 · Soluble immunoglobulin M (IgM) forms a pentamer containing a joining (J) chain polypeptide. While IgM pentamer has various immune functions, it also behaves as a carrier of circulating apoptosis inhibitor of macrophage (AIM; also called CD5L) protein that facilitates repair during different diseases. nsw health return to work after covid
jchain Gene Target - PubChem
WebApr 10, 2024 · Polymeric immunoglobulin receptor (pIgR) can bind and transport immunoglobulins (Igs), thus playing a role in mucosal immunity. In this study, pIgR gene was cloned in mandarin fish, Siniperca chuatsi, with the open reading frame (ORF) of 1011 bp, encoding 336 amino acids.The pIgR protein consists of a signal peptide, an extracellular … WebImmunoglobulin J-Chains. A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of … WebMay 12, 2024 · Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). nike christmas tree ornament